Since 1998, I have focused on the mechanisms of chronic inflammatory diseases and how various stressors initiate cases of such diseases. The local mechanism involved in such many such diseases, called the NO/ONOO- cycle, has been recently been confirmed in a recent 57 page paper on heart failure, and to a lesser extent in a recent paper in pulmonary hypertension. I have focused in recent years on how stressors cause human disease, with special emphasis on electromagnetic fields (EMFs) and also chemicals. Non-ionizing, low-intensity EMFs act primarily via activation of voltage-gate calcium channels (VGCCs) and to a lesser extent activation of other voltage-gated ion channels via forces on their voltage sensor. VGCCs act via calcium signaling and the peroxynitrite pathway.